Plasminogen Activator Inhibitor-1 and Thrombotic Cerebrovascular Diseases
نویسندگان
چکیده
منابع مشابه
Plasminogen activator inhibitor-1 and thrombotic cerebrovascular diseases.
Alterations in thrombosis and fibrinolysis comprise important parts of stroke pathophysiology. A key step in the fibrinolytic process includes the tissue-type plasminogen activator (tPA)-mediated conversion of the proenzyme plasminogen into the active protease plasmin, which in turn degrades the fibrin structure of intravascular thrombi. There are a number of review articles well summarizing mo...
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High plasma plasminogen activator inhibitor-i (PAI-1) activity is associated with insulin resistance and is correlated with hyperinsulinemia. The cellular origin of plasma PAI-1 in insulin resistance is not known. The hepatoma cell line Hep G2 has been shown to synthesize PAI-1 in response to insulin. The aim of this study was to analyze the insulin-mediated response of PAI-1 and lipid synthesi...
متن کاملType 1 Plasminogen Activator Inhibitor
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متن کاملSerum Level of Plasminogen Activator Inhibitor Type-1 in Addicted Patients with Coronary Artery Disease
Background: Plasminogen activator inhibitor-1 (PAI-1) is a glycoprotein with inhibitory effects on the formation of plasmin from plasminogen by plasminogen activator. Thus, it prevents clot lysis in vessel walls. Several evidences prove the relationship between coronary artery disease and response to fibrinolytic therapy in patients with myocardial infarction with PAI-1 level. Opium addiction i...
متن کاملTissue plasminogen activator, plasminogen activator inhibitor-1, and tissue plasminogen activator/plasminogen activator inhibitor-1 complex as risk factors for the development of a first stroke.
UNLABELLED BACKGROUND NAD PURPOSE: Abnormalities in the fibrinolytic system have been associated with an increased risk for stroke in a few studies. This study was designed to test whether plasma levels of tissue plasminogen activator (tPA), plasminogen activator inhibitor-1 (PAI-1), and tPA/PAI-1 complex could predict a first-ever stroke. METHODS The study was an incident case-control study ...
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ژورنال
عنوان ژورنال: Stroke
سال: 2012
ISSN: 0039-2499,1524-4628
DOI: 10.1161/strokeaha.111.622217